Preparation and in vitro study on diffusion of capsaicin cubosome / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 644-647, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-300176
ABSTRACT
This study was to investigate the permeability and absorbability of capsaicin cubosome across abdominal skin of the SD rats in vitro. Diffusion of capsaicin cubosome and cream was performed with the modified Franz diffusion cell technique. The capsaicin cubosome showed no enhancement of skin permeation within 24 hours. However, the deposition amounts of capsaicin in the rat skin in the cubosome group was markedly higher than those in the commercial cream group (P < 0.01). Cubosome showed excellent characetristic of skin-targed which could be a good carrier for the local transdermal drug delivery system.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Permeability
/
Skin
/
Skin Absorption
/
Administration, Cutaneous
/
Kinetics
/
Capsaicin
/
Chemistry
/
Rats, Sprague-Dawley
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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