Relationship between the expression of cyclooxygenase-2 and microvessel density in oral squamnous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 431-433, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-300276
ABSTRACT
<p><b>OBJECTIVE</b>To detective the relationship between cyclooxygenase-2 (COX-2) and angiogenesis in oral squamous cell carcinoma (OSCC) and its clinical significance through observing the expression of COX-2 and determining microvessel density (MVD) in OSCC.</p><p><b>METHODS</b>PV-9000 immunohistochemistry was used to determine the expression of COX-2 and CD34, which was used to determine MVD, in 76 OSCC tissues and 12 normal oral mucosa tissues.</p><p><b>RESULTS</b>Overexpression of COX-2 was detected in OSCC, and was more intense compared with normal epithelium (P < 0.001). The high expression of COX-2 in OSCC was related to neck lymphnode metastasis, tumor size, TNM stage and histological grade (P <0.05). The MVD value in COX-2-positive group was much higher than that in COX-2-negative group (P < 0.01) and that in normal oral mucosa tissues (P < 0.01).</p><p><b>CONCLUSION</b>The high expression of COX-2 in OSCC was significantly associated with MVD, neck lymphnode metastasis, tumor size, TNM stage and histological grade. COX-2 might be one of the important factors in the angiogenesis of OSCC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mouth Neoplasms
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Cyclooxygenase 2
/
Microvessels
/
Lymphatic Metastasis
/
Mouth Mucosa
/
Neovascularization, Pathologic
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2005
Type:
Article
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