Detection and measurement of interleukin-8 in peri-implant crevicular fluid / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>Gingival crevicular fluid (GCF) analysis of various inflammatory mediators has been investigated as a means of providing objective criteria of peri-implant tissue health. In this report, the crevicular fluid levels of interleukin-8 (IL-8), GCF volume and clinical parameters were studied.</p><p><b>METHODS</b>GCF was sampled from 35 healthy and 35 inflamed sites of implantation patients. IL-8 levels were analysed using ABC-ELISA. Clinical parameters were measured, and data analysis was performed using the software package SPSS10.0.</p><p><b>RESULTS</b>Significant difference was observed between healthy implant sites and peri-implantitis sites. GCF volume was positively correlated with PD, PI, GI and MOB. The total amount of IL-8 was positively correlated with PD and GI.</p><p><b>CONCLUSION</b>This investigation suggested that GCF volume and IL-8 cytokine may be of value as a diagnostic and prognostic marker for peri-implantitis.</p>