Effect of hypoxia on the expression of urokinase-type plasminogen activator in human tongue squamous cell carcinoma cells (Tca8113) / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 211-213, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-300334
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expression of urokinase-type plasminogen activator (uPA) in human tongue squamous carcinoma cells (Tca8113) under hypoxia, in order to explore the relation between hypoxia and invasion and metastasis of oral cancer.</p><p><b>METHODS</b>Under different hypoxic times(0, 3, 6, 12, 24 h), the expression of uPA protein was examined quantitatively using immunohistochemical technique (IH) and flow cytometry (FCM).</p><p><b>RESULTS</b>Hypoxia promoted the expression of uPA. The longer hypoxic time was, the higher expression of uPA was.</p><p><b>CONCLUSION</b>Hypoxia can promote invasion and metastasis of oral squamous carcinoma through stimulating the expression of uPA.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mouth Neoplasms
/
Tongue Neoplasms
/
Carcinoma, Squamous Cell
/
Urokinase-Type Plasminogen Activator
/
Neoplasm Invasiveness
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2005
Type:
Article
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