Advances in application of Jurkat cell model in research on infectious diseases / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 236-242, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-300357
ABSTRACT
Infectious diseases can be caused by multiple pathogens, which can produce specific immune response in human body. The immune response produced by T cells is cellular immunity, which plays an important role in the anti-infection process of human body, and can participate in immunological protection and cause immunopathology. The outcome of various infectious diseases is closely related to cellular immune function, especially the function of T cells. Jurkat cells belong to the human acute T lymphocyte leukemia cell line. Jurkat cell model can simulate the function T lymphocytes, so it is widely used in the in vitro studies of T cell signal transduction, cytokines, and receptor expression, and can provide reference and guidance for the treatment of various infectious diseases and the research on their pathogenesis. The Jurkat cell model has been widely used in the in vitro studies of viral diseases and atypical pathogens, but parasitic infection studies using the Jurkat cell model are still rare. This article reviews advances in the application of Jurkat cell model in the research on infectious diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
T-Lymphocytes
/
Deltaretrovirus Infections
/
HIV Infections
/
Communicable Diseases
/
Jurkat Cells
/
Epstein-Barr Virus Infections
/
Enterovirus A, Human
/
Enterovirus Infections
/
Allergy and Immunology
Type of study:
Practice guideline
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2018
Type:
Article
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