Research advances in the association between transient receptor potential cation channel 6 and kidney disease / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 72-76, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-300388
ABSTRACT
Transient receptor potential cation channel 6 (TRPC6) is a member of the transient receptor superfamily encoded by the TRPC6 gene and is widely expressed in tissues and organs of the human body, especially in the glomerular podocytes. TRPC6 interacts with various slit diaphragm (SD) proteins including podocin, nephrin, ACTN4, and CD2AP to maintain the normal structure and function of glomerular podocytes. Foot process fusion caused by podocyte damage due to various factors is the most important morphological change in kidney disease. This article reviews the biological function of TRPC6 and its effect on kidney disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2018
Type:
Article
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