Clinical features of children with acute lymphoblastic leukemia complicated by pulmonary infection after chemotherapy / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1234-1238, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-300416
ABSTRACT
<p><b>OBJECTIVE</b>To examine the clinical features of children with acute lymphoblastic leukemia (ALL) complicated by pulmonary infection after chemotherapy.</p><p><b>METHODS</b>The clinical data of 108 ALL children (115 case-times) with post-chemotherapy pulmonary infection were retrospectively reviewed. The risk factors for pulmonary infection and the relationship between pathogens and chest CT findings were evaluated.</p><p><b>RESULTS</b>The highest incidence (77.4% ) of pulmonary infection occurred during remission induction, peaking at 31-60 days after chemotherapy. Patients with neutropenia had the highest incidence rate of pulmonary infection (67.0%). Bacteria (36%) and fungi (41%) were the two most common pathogens in the 41 patients who were etiologically suspected of or diagnosed with pulmonary infection. There was no significant difference in chest CT findings between patients with bacterial and fungal infections.</p><p><b>CONCLUSIONS</b>The children with ALL are most susceptible to pulmonary infection during remission induction, especially when they are neutropenic. Bacteria and fungi are the main pathogens of pulmonary infections in these patients. However, the changes in chest CT images are poor indicators of the nature of pulmonary infection.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Tract Infections
/
Diagnostic Imaging
/
Tomography, X-Ray Computed
/
Epidemiology
/
Retrospective Studies
/
Drug Therapy
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Microbiology
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2017
Type:
Article
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