The relationship between expression of interleukin-8 and prognosis of breast cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 900-903, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-300590
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of interleukin-8 (IL-8) and its prognostic significance in breast cancer.</p><p><b>METHODS</b>Expression of IL-8 in 113 breast cancers, 19 breast benign tumors and 20 breast normal tissues was examined by tissue microarray using immunohistochemistry, and the association of IL-8 expression with patient's clinico-pathological characteristics and prognosis was further analyzed.</p><p><b>RESULTS</b>The positive rate of IL-8 expression in breast cancer was 27.4%, which was significantly higher than that in benign tumor and normal tissue of breast (P = 0.002). IL-8 expression related to histological type (P = 0.040) and lymph node status (P = 0.021). The expression of IL-8 was observed to correlate negatively with ER and PR status (P = 0.015 and P = 0.034), and correlate positively with C-erbB-2 status (P = 0.002). In addition, Kaplan-Meier curves of disease-free survival analysis showed a significant difference between IL-8 positive groups and negative group (P = 0.031).</p><p><b>CONCLUSIONS</b>IL-8 might be a poor prognostic factor for human breast cancer, and also might be a novel molecular marker to predicate the occurrence and progression of breast cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Breast Neoplasms
/
Immunohistochemistry
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Interleukin-8
/
Receptor, ErbB-2
/
Diagnosis
/
Lymphatic Metastasis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2006
Type:
Article
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