Diagnosis and treatment of invasive aspergillosis infection following orthotopic liver transplantation / 中华外科杂志
Chinese Journal of Surgery
;
(12): 885-888, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-300594
ABSTRACT
<p><b>OBJECTIVE</b>To explore the treatment and appropriate management of invasive aspergillosis infection following orthotopic liver transplantation.</p><p><b>METHODS</b>The clinical data of 576 cases who underwent orthotopic liver transplantation consecutively between January 2000 and January 2005 were analyzed retrospectively.</p><p><b>RESULTS</b>The prevalence of invasive aspergillosis infection was 1.74 (9/576), included 8 cases with pulmonary aspergillosis and 1 case with cerebral aspergillosis. The interval between transplantation and diagnosis were from 10 days to 2 months. Persistent or discontinuous low fever maybe the main clinical presentation after operation. Liposomal amphotericin B (AmBisome) is the mainly treatment for invasive aspergillosis infections, 5 patients were cured and 2 patients developed multi-organ aspergillosis infection died.</p><p><b>CONCLUSIONS</b>The clinical features of invasive aspergillosis infection following orthotopic liver transplantation were un-typical presentations in the early stage and easy to disseminate. Appropriate modification of immunosuppression therapy and early, high dose and long-term application of antifungal treatment is effective and safe to cure the disease.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Complications
/
Aspergillosis
/
Amphotericin B
/
Retrospective Studies
/
Liver Transplantation
/
Neuroaspergillosis
/
Therapeutic Uses
/
Diagnosis
/
Drug Therapy
/
Lung Diseases, Fungal
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2006
Type:
Article
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