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The effect of ultra high molecular weight polyethylene particles on macrophage / 中华外科杂志
Chinese Journal of Surgery ; (12): 852-855, 2006.
Article in Chinese | WPRIM | ID: wpr-300597
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of ultra high molecular weight polyethylene (UHMWPE) particles on macrophages and evaluate the expression of NFAT2, a key transcriptional factor for osteoclast differentiation.</p><p><b>METHODS</b>From November 2004 to February 2005, macrophages were co-cultured with UHMWPE particles. When observed at different times, the proliferation activity of macrophages was analyzed by MTT and the expression of calcineurin (CaN) and NFAT2 by immunohistochemical and RT-PCR method respectively.</p><p><b>RESULTS</b>The macrophages phagocytosed UHMWPE particles in an early time, the expression of CaN and NFAT2 was increased, while the proliferation activity was not enhanced.</p><p><b>CONCLUSIONS</b>UHMWPE particles can stimulate macrophages to phagocytose significantly, and enhance the expression of the transcriptional factor NFAT2.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Phagocytosis / Pharmacology / Physiology / Polyethylenes / In Vitro Techniques / RNA, Messenger / NFATC Transcription Factors / Genetics / Joint Prosthesis / Macrophages Limits: Animals Language: Chinese Journal: Chinese Journal of Surgery Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phagocytosis / Pharmacology / Physiology / Polyethylenes / In Vitro Techniques / RNA, Messenger / NFATC Transcription Factors / Genetics / Joint Prosthesis / Macrophages Limits: Animals Language: Chinese Journal: Chinese Journal of Surgery Year: 2006 Type: Article