Effect of diethylstilbestrol on polyamine metabolism in hamster epididymis / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 301-306, 2003.
Article
in English
| WPRIM
| ID: wpr-300880
ABSTRACT
<p><b>AIM</b>To investigate the effect of diethylstilbestrol (DES), one of the most potent endocrine disruptors, on the metabolism of polyamines in hamster epididymis.</p><p><b>METHODS</b>Male golden hamsters of 7-week-old were kept under a light and dark cycle of 14 h and 10 h for 1 week to stimulate maximally the gonadal function. DES was injected subcutaneously at doses of 0.01 mg . kg(-1) . day(-1), 0.1 mg . kg(-1) . day(-1) and 1 mg . kg(-1) . day(-1) for one week.</p><p><b>RESULTS</b>DES treatment caused a significant decrease in the weight of epididymis. The activity of epididymal ornithine decarboxylase (ODC) increased 1 day after DES treatment, kept at a high level for 4 days and then decreased to nearly normal level at day 7. The activity of spermidine/spermine N1-acetyltransferase (SSAT) also increased transiently after DES treatment. The contents of putrescine, spermidine, spermine and N(1)-acetylspermidine were increased 1 day approximately 4 days after DES treatment and restored to normal at day 7. All these changes showed a marked difference between the caput and the cauda.</p><p><b>CONCLUSION</b>The polyamine biosynthesis in the hamster epididymis can be affected by DES, a xenoestrogen. DES may probably affect polyamine metabolism in the epididymis by regulating the rate-limiting enzymes involved in the polyamine biosynthesis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Ornithine Decarboxylase
/
Pharmacology
/
Polyamines
/
Acetyltransferases
/
Putrescine
/
Spermidine
/
Spermine
/
Mesocricetus
/
Diethylstilbestrol
Limits:
Animals
Language:
English
Journal:
Asian Journal of Andrology
Year:
2003
Type:
Article
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