Influences of dibutyryl cyclic adenosine monophosphate and forskolin on human sperm motility in vitro / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 113-115, 2003.
Article
in English
| WPRIM
| ID: wpr-300902
ABSTRACT
<p><b>AIM</b>To study the influences of dibutyryl cyclic adenosine monophosphate (dbcAMP) and forskolin on human sperm motility in vitro.</p><p><b>METHODS</b>Semen samples, aseptically obtained by masturbation and prepared by swim-up technique from 20 fertile men, were incubated with different concentrations of dbcAMP and forskolin at 37 deg. Measurements were carried out after 10 min, 20 min, 30 min and 60 min incubation. Motility parameters were estimated by using an automatic analyzing system.</p><p><b>RESULTS</b>Treatment with dbcAMP or forskolin resulted in a significant increase in sperm motility and progressive motility. The larger the concentrations of dbcAMP or forskolin, the greater the effect appeared. The straight linear velocity and curvilinear velocity were not affected by both agents.</p><p><b>CONCLUSION</b>dbcAMP and forskolin increase the motility and progressive motility of human sperm in vitro.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osmolar Concentration
/
Pharmacology
/
Sperm Motility
/
In Vitro Techniques
/
Colforsin
/
Bucladesine
/
Dose-Response Relationship, Drug
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2003
Type:
Article
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