C. elegans as a model system for Parkinson disease / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 124-128, 2006.
Article
in English
| WPRIM
| ID: wpr-300947
ABSTRACT
Parkinson disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra. Although investigation in mammalian animal models of PD has enhanced our understanding of PD, the complexity of the mammalian nervous system and our inability to visualize DA neurons in vivo restricts the advances in elucidating the molecular mechanisms of PD. Conservation between C. elegans and mammals in genomic, biosynthetic and metabolic pathways as well as the advantages of observing DA neurons morphology in vivo and the ease of transgenic and genetic manipulation make C. elegans an excellent model organism for PD.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Neuroscience Bulletin
Year:
2006
Type:
Article
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