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Effects of Shenfu Injection () on cerebral metabolism in a porcine model of cardiac arrest / 中国结合医学杂志
Chinese journal of integrative medicine ; (12): 33-39, 2017.
Article in English | WPRIM | ID: wpr-301038
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Shenfu Injection (, SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA).</p><p><b>METHODS</b>Thirty Wuzhishan minipigs were randomly assigned to the control group (n=6), epinephrine group (EP group, n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF), pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg), respectively. After successful resuscitation, cerebrospinal fluid (CSF) levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation (ROSC). In addition, neurologic defificit score (NDS) was calculated at 24 h after ROSC. Surviving pigs were killed at 24 h after ROSC, and the brain tissue was obtained for ultra-microstructure examination.</p><p><b>RESULTS</b>Compared with the EP group, CSF glucose and pyruvate levels were higher (all P<0.01), and lactate levels were lower in the Sfigroup (P<0.01). Meanwhile, CSF glutamate and glycerol levels in the Sfigroup were lower in comparison to the EP group (all P<0.05). In addition, Sfidecreased NDS at 24 h after ROSC (P<0.01), and alleviated the histopathological damage of the brain.</p><p><b>CONCLUSIONS</b>Sficould alleviate brain injury after CA, which may be associated with improving cerebral metabolism.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Perfusion / Pharmacology / Blood Circulation / Blood Gas Analysis / Brain / Drugs, Chinese Herbal / Cerebrospinal Fluid / Cardiopulmonary Resuscitation / Sus scrofa / Therapeutic Uses Type of study: Prognostic study Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Perfusion / Pharmacology / Blood Circulation / Blood Gas Analysis / Brain / Drugs, Chinese Herbal / Cerebrospinal Fluid / Cardiopulmonary Resuscitation / Sus scrofa / Therapeutic Uses Type of study: Prognostic study Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2017 Type: Article