Your browser doesn't support javascript.
loading
Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial / 中国结合医学杂志
Chinese journal of integrative medicine ; (12): 573-580, 2016.
Article in English | WPRIM | ID: wpr-301080
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical efficacy and safety of Yinchen Zhufu Decoction (, YCZFD) in the treatment of acute-on-chronic liver failure caused by hepatitis B virus (HBV-ACLF) with cold pattern in Chinese medicine (CM).</p><p><b>METHODS</b>This is a multi-center randomized controlled trial of integrative treatment of CM and Western medicine (WM) for the management of HBV-ACLF patients. A total of 200 HBV-ACLF patients with cold pattern were equally randomly assigned to receive YCZFD and WM (integrative treatment) or WM conventional therapy alone respectively for 4 weeks. The primary end point was the mortality for HBV-ACLF patients. Secondary outcome measures included Model for End-Stage Liver disease (MELD) score, liver biochemical function, coagulation function and complications. Adverse events during treatment were reported.</p><p><b>RESULTS</b>The mortality was decreased 14.28% in the integrative treatment group compared with WM group (χ(2) =6.156, P=0.013). The integrative treatment was found to signifificantly improve the MELD score (t=2.353, P=0.020). There were statistically signifificant differences in aspartate transaminase, total bilirubin, indirect bilirubin, direct bilirubin and prothrombin time between the two groups (P<0.05 or P<0.01). The complications of ascites (χ(2)=9.033, P=0.003) and spontaneous bacteria peritonitis (χ(2)=4.194, P=0.041) were improved signifificantly in the integrative treatment group. No serious adverse event was reported.</p><p><b>CONCLUSIONS</b>The integrative treatment of CM and WM was effective and safe for HBV-ACLF patients with cold pattern in CM. The Chinese therapeutic principle "treating cold pattern with hot herbs" remains valuable to the clinical therapy. (Trial registration No. ChiCTR-TRC-10000766).</p>
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Peritonitis / Pharmacology / Physiology / Ascites / Time Factors / Virology / Drugs, Chinese Herbal / Demography / Hepatitis B virus Type of study: Controlled clinical trial / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Chinese journal of integrative medicine Year: 2016 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Peritonitis / Pharmacology / Physiology / Ascites / Time Factors / Virology / Drugs, Chinese Herbal / Demography / Hepatitis B virus Type of study: Controlled clinical trial / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Chinese journal of integrative medicine Year: 2016 Type: Article