Therapeutic efficiency of amphotericin B liposome modified by RMP-7 to transport drug across blood brain barrier / 药学学报
Acta Pharmaceutica Sinica
;
(12): 292-295, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-301092
ABSTRACT
<p><b>AIM</b>To study the therapeutic efficiency of amphotericin B liposome (AmB-L) targeting to the brain in mice with meningitis.</p><p><b>METHODS</b>Amphotericin B liposome targeting to the brain were prepared by film-sonication method. Their concentration and encapsulation percentage were determined. The Candida albicans was injected into the brain of BALB/c mice and the meningitis model was set up. Then the therapeutic efficiency of amphotericin B liposome targeting to the brain was studied.</p><p><b>RESULTS</b>The encapsulation percentage of amphotericin B liposome was 93.3%. The meningitis model was set up after the Candida albicans was injected into the brain of BALB/c mice for 2 h. The therapeutic efficiency was increased after conjugating RMP-7 (the commercial nama is Cereport) to the surface of amphotericin B liposome.</p><p><b>CONCLUSION</b>The therapeutic efficiency of Amphotericin B liposome targeting to the brain in the mice with meningitis was better than that of the common amphotericin B liposome and the life of the mice in AmB-L-PEG-RMP-7 group was longer than that of the mice in AmB-L-PEG group and AmB-L-PEG + RMP-7 group.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Biological Transport
/
Brain
/
Candida albicans
/
Bradykinin
/
Pharmacokinetics
/
Blood-Brain Barrier
/
Amphotericin B
/
Meningitis, Fungal
/
Drug Delivery Systems
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article
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