Comparison of genetic polymorphism of cytochrome CYP2C19 between men and women in Chinese population / 药学学报
Acta Pharmaceutica Sinica
;
(12): 161-163, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-301124
ABSTRACT
<p><b>AIM</b>To assess the effect of gender on genetic polymorphism of cytochrome CYP2C19 in Chinese population.</p><p><b>METHODS</b>The genetic polymorphism of 140 healthy Chinese were analysed by PCR-RFLP (restriction fragment length polymorphism).</p><p><b>RESULTS</b>Of 52 genotyped male subjects, 23 (44.23%) were homozygous for wildtype (wt/wt), 6 (11.54%) were homozygous for CYP2C19 m1 (m1/m1), and 23 (44.23%) were heterozygous for CYP2C19 m1 or CYP2C19 m2 (wt/m1 or wt/m2); and among the 88 genotyped female subjects, 31 (35.23%) were homozygous for wildtype (wt/wt), 13 (14.82%) were homozygous for CYP2C19 m1 (m1/m1), and 44 (50.0%) were heterozygous for CYP2C19 m1 or CYP2C19 m2 (wt/m1 or wt/m2); no homozygous genotype for CYP2C19 m2 (m2/m2) was found in the study.</p><p><b>CONCLUSION</b>There is no statistical difference in ocurance of wt/wt and m1/m1 between in male and in female, so gender have no significant effect on genetic polymorphism of cytochrome CYP2C19.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Restriction Fragment Length
/
Aryl Hydrocarbon Hydroxylases
/
China
/
Sex Factors
/
Polymerase Chain Reaction
/
Asian People
/
Cytochrome P-450 CYP2C19
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article
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