Activation of Ca(2+)-activated K+ channels by oxyphenamone in rabbit mesenteric vascular smooth muscle cells / 药学学报
Acta Pharmaceutica Sinica
;
(12): 101-104, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-301138
ABSTRACT
<p><b>AIM</b>To study the effects of oxyphenamone (Oxy) on activation of Ca(2+)-activated K+ channels in rabbit mesenteric vascular smooth muscle cells.</p><p><b>METHODS</b>To measure the effect of Oxy on the Ca(2+)-activated K+ channel (BK (Ca) channel) activity in rabbit mesenteric vascular smooth muscle cells by using whole cell patch clamp techniques.</p><p><b>RESULTS</b>Oxy reversibly increase BK (Ca) channel activity in rabbit mesenteric artery smooth muscle cells. Application of Oxy (0.1 mumol.L-1) to the perfusion solution caused significant increase in outward currents and its effect was completely abolished by washout; The outward currents K+ was inhibited by TEA (7.5 mmol.L-1); Oxy activated the BK (Ca) channel in a dose-dependent manner (0.01-10 mumol.L-1).</p><p><b>CONCLUSION</b>Oxy directly increase the activity of BK (Ca) channel activity in rabbit mesenteric vascular smooth muscle cells in dose-dependent manner.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organic Chemicals
/
Pharmacology
/
Physiology
/
Cardiotonic Agents
/
Patch-Clamp Techniques
/
Cell Biology
/
Potassium Channels, Calcium-Activated
/
Myocytes, Smooth Muscle
/
Mesenteric Arteries
/
Muscle, Smooth, Vascular
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article
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