Study on preparation conditions for polylactide nanoparticles loaded cyclosporine A and its oral bioavailability in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 68-71, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-301146
ABSTRACT
<p><b>AIM</b>To develop a less toxic alternative for sandimmun neoral (Neoral). To study the preparation conditions and to compare its pharmacokinetic characteristics with Neoral.</p><p><b>METHODS</b>Polylactide nanoparticles loaded cyclosporine A was prepared by solvent-nonsolvent method. Polylactide nanoparticles were administered by oral in a dosage of 15 mg.kg-1. The CyA concentration in whole blood sample was determined by HPLC.</p><p><b>RESULTS</b>The quantities of CyA, PLA and volume of acetone added had significant influence on the NP diameters. Under proper condition, the nanoparticles with diameters of 57.5 nm were obtained. The relative bioavailability in rats was 101.6%, with a smaller absorption rate (P < 0.05) and a smaller elimination rate (P < 0.1).</p><p><b>CONCLUSION</b>The nanoparticles (diamater < 100 nm) with relative high bioavailability were prepared using solvent-nonsolvent method. It is suitable for further study.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyesters
/
Pharmacokinetics
/
Biological Availability
/
Random Allocation
/
Administration, Oral
/
Cyclosporine
/
Rats, Wistar
/
Nanotechnology
/
Delayed-Action Preparations
/
Immunosuppressive Agents
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article
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