Synthesis and antitumor activity of the derivatives of cephalotaxine and drupacine / 药学学报
Acta Pharmaceutica Sinica
;
(12): 919-923, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-301175
ABSTRACT
<p><b>AIM</b>To make full use of cephalotaxus plant resources and search for antitumor agents with higher activities and lower side effects.</p><p><b>METHODS</b>The C3 hydroxy groups of the cephlotaxine and drupacine were acylated by taxol side chain and its isomers to give a series of derivatives of cephlotaxine and drupacine.</p><p><b>RESULTS</b>Six novel alkaloid esters were designed and synthesized. The pharmacological screening results showed that VIIIa, VIIIb, IXa and IXc exhibited significant activities on KB, HCT and Bel in vitro.</p><p><b>CONCLUSION</b>Novel alkaloid esters are worthy to be intensively studied.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Tumor Cells, Cultured
/
KB Cells
/
Chemistry
/
Colonic Neoplasms
/
Carcinoma, Hepatocellular
/
Harringtonines
/
Liver Neoplasms
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article
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