Inhibitory action of berberine on glucose absorption / 药学学报
Acta Pharmaceutica Sinica
;
(12): 911-914, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-301177
ABSTRACT
<p><b>AIM</b>To study the absorption characteristics of berberine and its influence on glucose absorption.</p><p><b>METHODS</b>Rat recirculating perfusion model was used to study berberine absorption characteristics and Caco-2 cell model was used to explore the influence of berberine on disaccharidase, using HPLC to assay the appearance of glucose to indicate enzyme activities.</p><p><b>RESULTS</b>Berberine was found to be hardly absorbed in the intestine (less than 5% in 2.5 h). However, sucrase and maltase activities were found to be inhibited by berberine, its ID50 to sucrase is 1.830 mg.L-1, and showed no dose dependent influence on maltase activity. Berberine also showed influence on glucose absorption. However, this effect is not significant.</p><p><b>CONCLUSION</b>Berberine may act as an alpha-glucosidase inhibitor, which is its main mechanism in diabetes treatment.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Sucrase
/
Berberine
/
Pharmacokinetics
/
Rats, Sprague-Dawley
/
Caco-2 Cells
/
Glycoside Hydrolase Inhibitors
/
Glucose
/
Hypoglycemic Agents
/
Intestinal Absorption
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article
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