Effects of conjugated linoleic acid on obese MSG mice with insulin resistance / 药学学报
Acta Pharmaceutica Sinica
;
(12): 904-907, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-301179
ABSTRACT
<p><b>AIM</b>To study the effect of conjugated linoleic acid (CLA) on obese MSG mice with insulin resistance.</p><p><b>METHODS</b>About four months old, obese MSG mice with insulin resistance were divided into control, CLA and rosiglitazone groups and drugs were administrated ig once a day. Body weights were recorded regularly, insulin and glucose tolerance were tested. In addition, serum insulin and TNF-alpha concentrations in serum and fat tissues were determined.</p><p><b>RESULTS</b>CLA was shown to reduce the body weight and fat weight in MSG mice, but can not improve the abnormal insulin and glucose tolerance in these mice. Indeed, the serum insulin and TNF-alpha concentrations in the fat tissues of the group treated with CLA were higher than those in the models and the insulin sensitivity index was significantly lower than that in the model mice.</p><p><b>CONCLUSION</b>CLA can reduce the body weight of MSG mice, but can not improve the insulin resistance in these mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Sodium Glutamate
/
Blood
/
Blood Glucose
/
Body Weight
/
Insulin Resistance
/
Adipose Tissue
/
Tumor Necrosis Factor-alpha
/
Linoleic Acids, Conjugated
/
Glucose Tolerance Test
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article
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