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A Meta-analysis of prothrombin G20210A polymorphism and its risk for sudden sensorineural hearing loss / 中华耳鼻咽喉头颈外科杂志
Article in Chinese | WPRIM | ID: wpr-301455
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between prothrombin G20210A polymorphism and the risk for idiopathic sudden sensorineural hearing loss (ISSNHL) using Meta-analysis methodology.</p><p><b>METHODS</b>Databases, including PUBMED, EMBASE, Cochrane Library and CBM, were searched to collect the case control studies on the correlation between prothrombin G20210A polymorphism and idiopathic sudden sensorineural hearing loss. Only high quality studies were included. All analysis were conducted with Review Manager Version 4.2 software.</p><p><b>RESULTS</b>A total of 9 studies were included, involving 735 cases and 1230 controls. The quality assessment involved 3 parts, 8 scores (totally 8 stars). The results showed the included studies were high-quality. Two studies were 8 stars of quality, three studies were 7 stars, one study was 6 stars, one study was 5 stars, and two studies were 4 stars. Meta-analysis showed that the prothrombin G20210A mutation frequencies of the genotypes and alleles showed significant statistically difference between cases and controls [P = 0.03, OR = 1.79, 95% CI = (1.06, 3.01); P = 0.03, OR = 1.77, 95% CI = (1.06, 2.97), respectively].</p><p><b>CONCLUSIONS</b>The prothrombin G20210A polymorphism might be a genetic risk factor for sudden hearing loss. However, this conclusion remains to be confirmed by high-quality, large-scale studies.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Humans / Prothrombin / Case-Control Studies / Epidemiology / Risk Factors / Thrombophilia / Hearing Loss, Sudden / Genetics / Genotype Type of study: Systematic reviews Language: Chinese Journal: Chinese Journal of Otorhinolaryngology Head and Neck Surgery Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Humans / Prothrombin / Case-Control Studies / Epidemiology / Risk Factors / Thrombophilia / Hearing Loss, Sudden / Genetics / Genotype Type of study: Systematic reviews Language: Chinese Journal: Chinese Journal of Otorhinolaryngology Head and Neck Surgery Year: 2013 Type: Article