Effect of hypoxia on activation of the peripheral blood T lymphocyte in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 145-148, 2011.
Article
in Zh
| WPRIM
| ID: wpr-301479
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of hypoxia on the peripheral blood T lymphocyte subsets and co-stimulatory molecules in rats so as to provide the basis for studying the intervention measure.</p><p><b>METHODS</b>Before hypoxia and during hypoxia at 8 000 m for 8 h, 3 d, 6 d and 10 d the change of peripheral blood T lymphocyte subsets and co-stimulatory molecules in rats were detected by flowcytometer with three-color immunofluorescence label.</p><p><b>RESULTS</b>Rats were exposed to hypoxia at 8 000 m for 8 hours, and CD3+, CD8+, CD8+ CD28- lymphocyte percentages were significantly decreased (P < 0.01) compared with that before hypoxia. After 3 days of hypoxia, besides aforesaid change, CD4+ CD28+ lymphocyte percentage also prominently decreased (P < 0.01) and CD4+ CD28- prominently increased (P < 0.01). After 6 and 10 days of hypoxia, CD3+, CD4+ lymphocyte percentages were further decreased, while CD8+ CD28+ lymphocyte percentage significantly increased (P < 0.01).</p><p><b>CONCLUSION</b>After exposed to hypoxia at 8 000 m for 8 hours and 3 days, activation of CD8+ and CD4+ T lymphocyte was prominently decreased, while with the prolong of exposed time activation of CD8+ T lymphocyte was significantly increased.</p>
Full text:
1
Index:
WPRIM
Main subject:
Physiology
/
Lymphocyte Activation
/
T-Lymphocytes
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CD4-Positive T-Lymphocytes
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Rats, Wistar
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CD8-Positive T-Lymphocytes
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Allergy and Immunology
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Altitude
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Altitude Sickness
/
Hypoxia
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Applied Physiology
Year:
2011
Type:
Article