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Effect of hypoxia on activation of the peripheral blood T lymphocyte in rats / 中国应用生理学杂志
Article in Zh | WPRIM | ID: wpr-301479
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of hypoxia on the peripheral blood T lymphocyte subsets and co-stimulatory molecules in rats so as to provide the basis for studying the intervention measure.</p><p><b>METHODS</b>Before hypoxia and during hypoxia at 8 000 m for 8 h, 3 d, 6 d and 10 d the change of peripheral blood T lymphocyte subsets and co-stimulatory molecules in rats were detected by flowcytometer with three-color immunofluorescence label.</p><p><b>RESULTS</b>Rats were exposed to hypoxia at 8 000 m for 8 hours, and CD3+, CD8+, CD8+ CD28- lymphocyte percentages were significantly decreased (P < 0.01) compared with that before hypoxia. After 3 days of hypoxia, besides aforesaid change, CD4+ CD28+ lymphocyte percentage also prominently decreased (P < 0.01) and CD4+ CD28- prominently increased (P < 0.01). After 6 and 10 days of hypoxia, CD3+, CD4+ lymphocyte percentages were further decreased, while CD8+ CD28+ lymphocyte percentage significantly increased (P < 0.01).</p><p><b>CONCLUSION</b>After exposed to hypoxia at 8 000 m for 8 hours and 3 days, activation of CD8+ and CD4+ T lymphocyte was prominently decreased, while with the prolong of exposed time activation of CD8+ T lymphocyte was significantly increased.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Physiology / Lymphocyte Activation / T-Lymphocytes / CD4-Positive T-Lymphocytes / Rats, Wistar / CD8-Positive T-Lymphocytes / Allergy and Immunology / Altitude / Altitude Sickness / Hypoxia Limits: Animals Language: Zh Journal: Chinese Journal of Applied Physiology Year: 2011 Type: Article
Full text: 1 Index: WPRIM Main subject: Physiology / Lymphocyte Activation / T-Lymphocytes / CD4-Positive T-Lymphocytes / Rats, Wistar / CD8-Positive T-Lymphocytes / Allergy and Immunology / Altitude / Altitude Sickness / Hypoxia Limits: Animals Language: Zh Journal: Chinese Journal of Applied Physiology Year: 2011 Type: Article