Molecular mechanisms involved in the treatment of inflammatory bowel disease by Pulsatilla decoction / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 106-109, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-301489
ABSTRACT
<p><b>OBJECTIVE</b>To investigate molecular mechanisms underlying in the treatment of inflammatory bowel disease by Pulsatilla decoction.</p><p><b>METHODS</b>Wistar male rats were randomly divided into control group, model group, model + positive control group (mesalazine), traditional Chinese medicine treatment group, in addition, the Chinese medical treatment group was divided into middle and high dose group ( n = 8). Intragastric administration was used in the positive control group and traditional Chinese medicine treatment group. The expression of Smad7 and p-Smad3 in the colons were detected by immunohistochemistry and Western blot.</p><p><b>RESULTS</b>Compared with the model group, positive medicine and traditional Chinese medicine group, especially high-dose group, could effectively inhibit the expression of Smad7, while enhancing the p-Smad3 expression.</p><p><b>CONCLUSION</b>The activation of TGF-beta1/Smad3 signaling pathway may be the molecular mechanism underlying in the anti-inflammatory effect of inflammatory bowel disease by Pulsatilla decoction.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Inflammatory Bowel Diseases
/
Signal Transduction
/
Chemistry
/
Rats, Wistar
/
Pulsatilla
/
Therapeutic Uses
/
Drug Therapy
/
Smad7 Protein
/
Smad3 Protein
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2011
Type:
Article
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