The study on local field potentials in rat's primary motor cortex during pressing paddle behavior / 中国应用生理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>The local field potential (LFP) is a summation of dendritic potentials. The main objective of the present work is to view the features of LFP in M1 during the experimental rat pushed a paddle with the right forelimb.</p><p><b>METHODS</b>Four rats were trained to press a paddle with the right forelimb for water. Then Two bundle micro-electrode with four channels were implanted into the rat's left and right primary motor cortex (M1)(AP + 3.0 mm, ML +/- 1.6 mm, H-1.6 mm) with stereotaxic apparatus. After three days recovery, 8-channel Deep-EEG and the pulse signal of paddle pressed were recorded during the rats were in operant chamber, and at the same time, the behavior were also recorded with video recorder.</p><p><b>RESULTS</b>The LFP in left M1 were defined as the substance between two channel deep-EEG. It is found that low frequency, high amplitude signal appear aligned with the paddle pressed pulse signals. With threshold detect method, about 80% press-paddle behavior could be detected.</p><p><b>CONCLUSION</b>The result indicates that LFPs in this position in M1 are relative to forelimb's movement, and a powerful brain-computer interface system maybe developed with the LFPs.</p>