Effects of kappa-opioid receptor stimulation on high glucose induced myocardial hypertrophy of neonatal rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 463-465, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-301535
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of kappa-opioid receptor stimulation on high glucose induced myocardial hypertrophy of neonatal rats.</p><p><b>METHODS</b>Using cultured myocardial cells as a model, the protein content was assayed with Lowrys method. The cardiomyocytes volumes were measured by computer photograph analysis system. The level of p-ERK44/42 was determined by Western blot.</p><p><b>RESULTS</b>Compared with the control, U50488H significantly inhibited the protein content and volumes of cultured hypertrophic myocardial cells induced by high glucose. Meanwhile the role of ERK was important.</p><p><b>CONCLUSION</b>The stimulation of kappa-opioid can inhibit myocardial hypertrophy induced by high glucose, which is possibly via attenuating p-ERK.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Cells, Cultured
/
Rats, Sprague-Dawley
/
Cardiomegaly
/
Receptors, Opioid, kappa
/
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
/
MAP Kinase Signaling System
/
Myocytes, Cardiac
/
Glucose
/
Animals, Newborn
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2010
Type:
Article
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