The protective effect of melatonin on auditory cortex toxicity induced by cis-platinum / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 539-542, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-301566
ABSTRACT
<p><b>AIM</b>To investigate the toxic response in auditory cortex of guinea pigs caused by cis-platinum (DDP), and the protective role of melatonin in this effect.</p><p><b>METHODS</b>Cis-platinum and melatonin were injected peritoneally. LDH, MDA, NO in the auditory cortex were detected by spectrophotometeR.</p><p><b>RESULTS</b>The body weight of the guinea pigs was diminished by peritoneal injection of Cis-platinum for 7 days (P < 0.01). Peritoneal injection of Cis-platinum induced the increased leakage of LDH (P < 0.05 vs injection of normal saline). This effect was reduced by injection of MT (P < 0.05). The content of MDA in the auditory cortex was also increased because of injection of Cis-platinumv for 7 days (P < 0.01) and MT reduced this effect (P < 0.05). The change of NO in the auditory cortex was not statistically significant after injection of Cis-platinum or Cis-platinum with MT.</p><p><b>CONCLUSION</b>Peritoneal injection of Cis-platinum could destroy neurons in the auditory cortex. This effect could be reduced by melatonin by an anti-free radials mechanism.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Auditory Cortex
/
Random Allocation
/
Free Radical Scavengers
/
Cisplatin
/
Toxicity
/
Guinea Pigs
/
Malondialdehyde
/
Melatonin
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2009
Type:
Article
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