Utilization of targeting specific proteins for ubiquitination and degradation / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 123-127, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-301582
ABSTRACT
Ubiquitin-proteasome pathway (UPP) can degrade specific proteins in eukaryotic cells. Targeting specific proteins for ubiquitination and degradation technique, based the theory of UPP and using certain chimeric E3s or protein-targeting chimeric molecules, can specifically knock down the targeted proteins. It is a promising new method for exploring the functions of genes or proteins and, together with gene-silencing technique, may play an important role in basic and clinical research.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Recombinant Proteins
/
Protein Transport
/
Ubiquitin-Protein Ligases
/
Proteasome Endopeptidase Complex
/
Ubiquitination
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2010
Type:
Article
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