Association between monoamine oxidase A gene and major depression in Chinese Han population / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 728-734, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-301618
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association between monoamine oxidase A (MAOA) variable number tandem repeat (VNTR) polymorphism and major depression in Chinese Han population.</p><p><b>METHODS</b>Polymerase chain reaction was used to genotype MAOA VNTR polymorphism. A total of 512 major depression patients and 566 normal controls were recruited in our study. These patients were also assessed using the 14-item Hamilton anxiety scale. RESULTS The allele frequency of MAOA VNTR was not significantly different between the male/female major depression patients and the normal controls. Compared with the normal controls, MAOA VNTR genotype was significantly more frequent in female major depression patients (P=0.002), but not in male patients (P=0.17). MAOA VNTR-L carrier was also associated with "fear" symptom in female patients (P=0.0056).</p><p><b>CONCLUSION</b>MAOA gene is associated with the major depression in Chinese Han population, especially among female patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Case-Control Studies
/
China
/
Promoter Regions, Genetic
/
Minisatellite Repeats
/
Genetic Predisposition to Disease
/
Asian People
/
Depressive Disorder, Major
/
Genetics
/
Monoamine Oxidase
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2009
Type:
Article
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