Evaluation of nCD64 and CD14 Index as Diagnostic Markers for Hematologic Tumors Combined with Bacterial Infection / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the value of both CD64(nCD64 IND) and CD14 (CD14 IND) Index of peripheral blood neutrophils as the diagnostic markers of hematologic tumors combined with bacterial infection.</p><p><b>METHODS</b>Sixty-four patients with hematological tumors were selected and divided into the group complicated with bacterial infection (infection group, 33 cases) and the non-infection group (31 cases), the flow cytometry was be used to detect the related peripheral blood markers CD64 and CD14, the nCD64 IND and CD14 IND were calculated, and the peripheral blood WBC count, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were determined at the same time.</p><p><b>RESULTS</b>The differences of nCD64 IND and CRP between these 2 groups were statistically significant (P<0.05), however, the differences of CD14IND, ESR and WBC between these 2 groups were not statistically significant(P>0.05). The receiver operating curves (ROC) were drawn by using the data of all indictors in the 2 groups, and the order of the area under the curve(AUC) from big to small size was as follows nCD64IND(0.974)>CRP(0.786)>ESR(0.675)>WBC(0.598)>CD14IND(0.556). The AUC of nCD64IND, CRP and ESR were statistically significantly different from the standard area of 0.5(P<0.05), while the AUC of CD14 IND,WBC were not statistically significantly different from the standard area of 0.5(P>0.05).</p><p><b>CONCLUSION</b>nCD64 possesses a high diagnostic value for hematologic tumors with bacterial infection, it's sensitivity and specificity both are higher than that of CRP and ESR.</p>