Research progress on MAPK signal pathway in the pathogenesis of osteoarthritis / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 441-444, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-301797
ABSTRACT
Mitogen-activated protein kinases (MAPKs) signal is one of the important ways in eukaryotic cell,which adjusts and controls the structure and function of the cell. MAPKs in eukaryotes include p38, ERK, JNK and ERK5, etc. With the deepening research,we found that the activation of p38, ERK, JNK signal pathways were closely related with osteoarthritis (OA) cartilage injury. MAPKs are the key signaling systems involved in the production of matrix metalloproteinases and the regulation of cartilage cell proliferation, apoptosis and differentiation. Expecially the matrix metalloproteinases can accelerate the degradation of articular cartilage. So it has been the new spot in pathogenesis of osteoarthritis study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Pathology
/
Cartilage, Articular
/
Mitogen-Activated Protein Kinases
/
MAP Kinase Signaling System
/
Metabolism
Type of study:
Etiology study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2014
Type:
Article
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