Your browser doesn't support javascript.
loading
Hedgehog signaling pathway and osteoporosis / 中国骨伤
China Journal of Orthopaedics and Traumatology ; (12): 169-172, 2014.
Article in Chinese | WPRIM | ID: wpr-301865
ABSTRACT
Hedgehog signaling pathway is a conserved and important signaling pathway involved in proliferation and differentiation of many types of cells. Latest studies have found that Hedgehog signaling pathway may induce MSCs osteoblast differentiation by increasing the expression of the Runx2 and Osx and inhibit MSCs differentiate to adipocyte. Hedgehog signaling pathway may also promote osteoblast proliferation by regulating cyclin. This review summarizes the mechanism that Hedgehog signaling pathway regulates osteoblast differentiation and proliferation,and concludes that Hedgehog signaling pathway can regulate bone metabolism. It might provide new ideas for the treatment of osteoporosis.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoblasts / Osteoporosis / Physiology / Transcription Factors / Signal Transduction / Cell Differentiation / Cell Biology / Drug Therapy / Core Binding Factor Alpha 1 Subunit / Hedgehog Proteins Limits: Humans Language: Chinese Journal: China Journal of Orthopaedics and Traumatology Year: 2014 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoblasts / Osteoporosis / Physiology / Transcription Factors / Signal Transduction / Cell Differentiation / Cell Biology / Drug Therapy / Core Binding Factor Alpha 1 Subunit / Hedgehog Proteins Limits: Humans Language: Chinese Journal: China Journal of Orthopaedics and Traumatology Year: 2014 Type: Article