Correlation between epidermal growth factor and overexpression of vascular endothelial growth factor in hepatocellular carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 564-566, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-301935
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between epidermal growth factor (EGF) and overexpression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>Expressions of EGF, VEGF and microvessel density were studied through immunohistochemical SABC method in 36 HCC specimens, their paraneoplastic liver tissues and 6 normal liver tissues with the correlation between these parameters analyzed. Recombinant human EGF was used to stimulate HepG(2) cells and semi-quantitative reverse transcription PCR was adopted to detect the expression of VEGF in HepG(2) cells.</p><p><b>RESULTS</b>The positive rates of EGF and VEGF expression in HCC tissue were 75.0% and 88.9%. There was positive correlation between EGF and VEGF expression (P < 0.01, r = 0.462). Recombinant human EGF could induce the expression of VEGF in HepG(2) cells in a dose and time dependent manner.</p><p><b>CONCLUSION</b>The expression of EGF in HCC underlies the overexpression of VEGF in HCC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Statistics as Topic
/
Endothelial Growth Factors
/
Lymphokines
/
Carcinoma, Hepatocellular
/
Intercellular Signaling Peptides and Proteins
/
Vascular Endothelial Growth Factors
/
Vascular Endothelial Growth Factor A
/
Epidermal Growth Factor
/
Liver Neoplasms
/
Metabolism
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2002
Type:
Article
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