Assessment of nasopharyngeal carcinoma risk by EB virus antibody profile / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 561-563, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-301936
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the risk of nasopharyngeal carcinoma (NPC) through EB virus antibody profile by enzyme linked immunosorbent assay (ELISA).</p><p><b>METHODS</b>EBNA 1/IgA, EBNA 1/IgG and zta/IgG by ELISA and VCA/IgA by immmunoenzymatic method were detected in 121 NPC patients and 332 healthy subjects (HS) in the Pearl river estuary.</p><p><b>RESULTS</b>The sensitivity rates were 85%, 83% and 79% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was the highest 92%. The specificity rates were 86%, 86% and 80% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was also the highest 93%. According to the level of odds ratio, nasopharyngeal carcinoma risk could be divided into 3 groups low, moderate and high-risk groups. 93% of HS had low risk of NPC with the odds ratio 0.0 to 0.3. 0.4% of HS had high risk of NPC with the odds ratio of 137.9%.</p><p><b>CONCLUSION</b>ELISA is more objective than the traditional immunoenzymatic method in the detection and diagnosis of NPC. The combination of EBNA 1/IgA, EBNA 1/IgG and zta/IgG is able to evaluate the risk of NPC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Enzyme-Linked Immunosorbent Assay
/
Nasopharyngeal Neoplasms
/
Risk Factors
/
Herpesvirus 4, Human
/
Epstein-Barr Virus Nuclear Antigens
/
Diagnosis
/
Antibodies, Viral
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2002
Type:
Article
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