Clinical trial of lentaron for postmenopausal patients with advanced breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 511-513, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-301973
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and adverse effects of lentaron for postmenopausal patients with recurrent and metastatic breast cancer.</p><p><b>METHODS</b>Thirty-four patients with recurrent and metastatic breast cancer received 250 mg lentaron by intramuscular injection every 2 weeks for at least one month.</p><p><b>RESULTS</b>In 34 patients who were evaluable for efficacy and toxicity, the complete response rate (CR), partial response rate (PR), disease stabilization rate (SD) and progressive disease rate (PD) were 0%, 14.7%, 58.8% and 26.5%. The clinical benefit rate (CR + PR + SD >/= 6 months) was 50.0%. (17/34) with 12 patients (35.3%) having SD for at least 6 months. The response rates for bone, soft tissue and visceral metastasis were 28.6% (3/14), 13.6% (3/22) and 5.3% (1/19), respectively. There were no severe adverse effects in the treatment bylentaron.</p><p><b>CONCLUSION</b>Lentaron is a well tolerated agent with reasonable efficacy but low toxicity for postmenopausal patients with recurrent and metastatic breast cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Breast Neoplasms
/
Treatment Outcome
/
Postmenopause
/
Disease Progression
/
Therapeutic Uses
/
Drug Therapy
/
Androstenedione
/
Neoplasm Metastasis
/
Neoplasm Staging
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2002
Type:
Article
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