Relationship between tissue factor expression and hepatic metastasis and prognosis in rectal cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 378-380, 2002.
Article
in English
| WPRIM
| ID: wpr-302006
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between tissue factor (TF) expression and hepatic metastasis and prognosis in rectal cancer.</p><p><b>METHODS</b>TF expression was retrospectively studied by immunohistochemical method in specimens of 40 rectal cancer, 3 hepatic metastasis and 6 benign adenoma with relation to their clinicopathologic data.</p><p><b>RESULTS</b>1. TF expression was detected in 20 (50%) of the 40 primary rectal cancer specimens and all the 3 hepatic metastatic specimens, but not in the 6 benign adenoma or normal mucosa of rectum, 2. Significant correlation was observed between TF expression and synchronic hepatic metastasis (P = 0.002) and heterochronic hepatic metastasis (P = 0.001) and 3. TF was a risk factor for the prognosis of primary rectal cancer (P = 0.024).</p><p><b>CONCLUSION</b>Tissue factor expression may play a role in the process of developing hepatic metastasis. It may be considered as a new clinical indicator for monitor of hepatic metastasis and prognosis of primary rectal cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Rectal Neoplasms
/
Rectum
/
Staining and Labeling
/
Thromboplastin
/
Immunohistochemistry
/
Adenoma
/
Logistic Models
/
Proportional Hazards Models
/
Predictive Value of Tests
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Oncology
Year:
2002
Type:
Article
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