Mitochondrial Energy Metabolism and Thyroid Cancers
Endocrinology and Metabolism
;
: 117-123, 2015.
Article
in English
| WPRIM
| ID: wpr-30203
ABSTRACT
Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhibition of oncogenic pathways did not provide a significant survival benefit in advanced progressive thyroid cancer that is resistant to radioactive iodine therapy. Accumulating evidence clearly shows that cellular energy metabolism, which is controlled by oncogenes and other tumor-related factors, is a critical factor determining the clinical phenotypes of cancer. However, the role and nature of energy metabolism in thyroid cancer remain unclear. In this article, we discuss the role of cellular energy metabolism, particularly mitochondrial energy metabolism, in thyroid cancer. Determining the molecular nature of metabolic remodeling in thyroid cancer may provide new biomarkers and therapeutic targets that may be useful in the management of refractory thyroid cancers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Phenotype
/
Thyroid Gland
/
Thyroid Neoplasms
/
Carcinoma
/
Biomarkers
/
Disease Progression
/
Energy Metabolism
/
Carcinogenesis
/
Iodine
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2015
Type:
Article
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