Meta-analysis of association between organophosphorus pesticides and aplastic anemia / 中华流行病学杂志

ABSTRACT

Objective To evaluate the association between organophosphorus pesticides and aplastic anemia,and provide scientific evidence for the primary prevention of aplastic anemia.Methods The published papers of case control studies on the association between organophosphorus pesticides and aplastic anemia from January 1990 to August 2014 were collected from Chinese BioMedical Literature Base (CBM),Chinese National Knowledge Infrastructure (CNKI),PubMed and EMBASE.The papers which met the inclusion criteria were evaluated.The pooled odds ratios (OR) and 95％ confidence interval (CI) of organophosphorus pesticides were calculated with software Review Manager 5.0.Subgroup analysis were conducted for different population and different usage of organophosphorus pesticides.Results A total of 9 papers were selected,involving 5 833 subjects (1 404 cases and 4 429 controls).The results showed that organophosphorus pesticides could increase the risk of aplastic anemia (OR=1.97,95％ CI1.60-2.44).Subgroup analysis showed that Asian (OR=2.01,95％CI1.52-2.66) had higher risk of aplastic anemia than American or European(OR=1.93,95％CI1.39-2.67).Using pure organophosphorus pesticides (OR=2.15,95％ CI1.60-2.88) was more prone to cause aplastic anemia than using the mixture of organophosphorus pesticides (OR=1.82,95％ CI1.34-2.47).Conclusion The analysis indicated that organophosphorus pesticides might be a risk factor for aplastic anemia.Reducing organophosphorus pesticides exposure in daily life and industrial or agricultural production could prevent the incidence of aplastic anemia.