CTCF as a multifunctional protein in genome regulation and gene expression
Experimental & Molecular Medicine
;
: e166-2015.
Article
in English
| WPRIM
| ID: wpr-30204
ABSTRACT
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator protein, blocking the communication between enhancers and promoters. CTCF can also recruit other transcription factors while bound to chromatin domain boundaries. The three-dimensional organization of the eukaryotic genome dictates its function, and CTCF serves as one of the core architectural proteins that help establish this organization. The mapping of CTCF-binding sites in diverse species has revealed that the genome is covered with CTCF-binding sites. Here we briefly describe the diverse roles of CTCF that contribute to genome organization and gene expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Repressor Proteins
/
Chromosomal Proteins, Non-Histone
/
Gene Expression Regulation
/
Genome
/
Cell Cycle Proteins
/
Protein Interaction Maps
Limits:
Animals
/
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2015
Type:
Article
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