Progress of study on the roles of matrix metalloproteinases in the pathogenesis of hematologic malignancies -- review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 229-233, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-302159
ABSTRACT
Matrix metalloproteinases (MMPs) have the ability to degrade extracellular matrix components. They abnormally express in a variety of solid tumors and hematologic malignancies, and play an important role in tumor invasion and metastasis through extracellular matrix degradation, which closely relates with the progression and prognosis of the malignant disease. This article reviews progress of study on the mechanism of MMP underlying the pathogenesis of hematologic malignancies, including structure of MMP, regulation mechanism of MMP and its relation with proliferation and differentiation of hematopoietic stem cells (HSC), angiogenesis and tumor immunology and so on.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Hematologic Neoplasms
/
Matrix Metalloproteinases
Type of study:
Etiology study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2009
Type:
Article
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