Etiological analysis of 67 cases of acute leukemia combined with fungal infection / 中国实验血液学杂志

ABSTRACT

In order to study the etiological distribution characteristics of fungal infection and improve the clinical therapeutic efficacy in acute leukemia (AL) patients, the fungal infection etiological distribution, infection site and cause were retrospectively analyzed in 67 cases of AL combined with fungal infection. The result indicated that 63 strains of pathogens were isolated from all detected samples. Infection sites involved oral cavity, low respiratory tract, gastrointestinal tract, blood and urethra; susceptible factors was correlated positively to the duration of administration of broad-spectral antibiotics, glucocorticoid and agranulocytosis. It is concluded that (1) Candida albicans accounts as the most of infection spectrum in AL; (2) main sites of invasive fungal infection are low respiratory tract (63.64%) and gastrointestinal tract (18.18%); (3) the susceptible factors to fungal infection are agranulocytosis and administration of broad-spectral antibiotics in acute leukemia patients; (4) there is interaction between the use of antibiotics and agranulocytosis for the same fungal infection, there is no relationship between long-term use of glucocorticoids and agranulocytosis, and also no relationship between long-term use of glucocorticoids and antibiotics.