Progress of improving blood donor screening by nucleic acid technology / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1171-1177, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-302325
ABSTRACT
With increasing application of blood transfusion, the research of side-effects such as transfusion-transmitted infections (TTIs) became more and more important. Up to the 90's of the 20th century, the first blood donor screening for pathogens transfected from blood transfusion entirely depended on serological test. At this time, the detection of virus were performed mainly by using method of detecting antibody, except hepatitis B virus (HBV) can be detected by hepatitis B surface antigen (HBsAg). Now, the molecular technologies, such as the polymerase chain reaction (PCR), have been used in clinic. These technologic methods can provide capability of detection for blood donor screening and reduced possibility of infection from blood transfusion. This review summarises the development of nucleic acid amplification technology and describes its current state.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
DNA, Viral
/
Mass Screening
/
Nucleic Acid Amplification Techniques
/
Donor Selection
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2014
Type:
Article
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