Endoplasmic reticulum stress and myocardial hypertrophy / 生理学报
Acta Physiologica Sinica
;
(6): 9-14, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-302488
ABSTRACT
Sarcoplasmic reticulum is a principal subcellular organelle which regulates calcium homeostasis, protein synthesis, and apoptosis of cardiomyocytes. Endoplasmic reticulum (ER) stress is defined as the perturbation of ER function which is caused by the alterations in the ER environment, such as the perturbation of Ca(2+) homeostasis, elevated protein synthesis, the deprivation of glucose, altered glycosylation, and the accumulation of misfolded proteins. Moderate ER stress is able to restore cellular homeostasis, i.e., to exert a compensatory effect on cardiomyocytes. However, intense or persistent ER stress may cause ER stress-induced apoptosis, which shifts the hypertrophied myocardium to failure, and affects the pathogenesis and development of myocardial hypertrophy. The article reviewed the role of ER stress response in the pathogenesis and development of myocardial hypertrophy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Sarcoplasmic Reticulum
/
Protein Biosynthesis
/
Apoptosis
/
Myocytes, Cardiac
/
Endoplasmic Reticulum Stress
/
Homeostasis
/
Hypertrophy
/
Myocardium
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2009
Type:
Article
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