A case of conventional antimitochondrial antibody test-negative primary biliary cirrhosis / 대한내과학회지
Korean Journal of Medicine
;
: 85-90, 2000.
Article
in Korean
| WPRIM
| ID: wpr-30260
ABSTRACT
Primary biliary cirrhosis is a chronic progressive cholestatic liver disease of unknown cause that usually affects middle-aged women and eventually leads to cirrhosis and liver failure. It is characterized by the progressive destruction of small intrahepatic bile ducts, portal inflammation, and progressive scarring. The diagnosis is made by these characteristic pathologic findings and the presence of antimitochondrial antibody. Immunofluorescence, the most widely used method for determining antimitochondrial antibody, is less sensitive and specific than ELISA or immunoblotting and influenced by observer interpretation. Therefore, it is important to detect anti-M2 antibody, the most specific antibody of primary biliary cirrhosis, by ELISA or immunoblotting when antimitochondrial antibody is not detected by immunofluorescence method which can lead to the incorrect diagnosis as autoimmune cholangitis. We describe a case of primary biliary cirrhosis with antimitochondrial antibody negative by immunofluorescence, anti-M2 antibody positive by ELISA. We confirmed primary biliary cirrhosis by liver biopsy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bile Ducts, Intrahepatic
/
Biopsy
/
Fibrosis
/
Enzyme-Linked Immunosorbent Assay
/
Immunoblotting
/
Cholangitis
/
Fluorescent Antibody Technique
/
Cicatrix
/
Liver Failure
/
Diagnosis
Type of study:
Diagnostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS