Distribution of hydroxycamptothecin after aerosol inhalation in rabbits / 药学学报
Acta Pharmaceutica Sinica
; (12): 747-751, 2004.
Article
in Zh
| WPRIM
| ID: wpr-302722
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the tissue distribution and pharmacokinetics of hydroxycamptothecin (HCPT) after aerosol inhalation in rabbits.</p><p><b>METHODS</b>RP-HPLC was used to determine the concentration of HCPT in different tissues and plasma of rabbits. The tissue distribution of HCPT after aerosol inhalation or iv administration was compared. The plasma concentrations at different time after aerosol inhalation were compared with iv injection.</p><p><b>RESULTS</b>The HCPT concentrations in lung after aerosol inhalation at 0.5, 1 and 2 h were 13.52, 27.81 and 20.82 times higher than that of iv administration group, respectively. At the same time, concentrations in other tissues were decreased obviously. The absolute bioavailability of HCPT after aerosol inhalation was 7.38%.</p><p><b>CONCLUSION</b>After aerosol inhalation, HCPT is retained mostly in lung. So this administration route can raise the therapeutic index and reduce adverse effects.</p>
Full text:
1
Index:
WPRIM
Main subject:
Blood
/
Administration, Inhalation
/
Camptothecin
/
Pharmacokinetics
/
Biological Availability
/
Tissue Distribution
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Injections, Intravenous
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Lung
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Metabolism
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Antineoplastic Agents, Phytogenic
Limits:
Animals
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article