Evaluation of in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method / 药学学报
Acta Pharmaceutica Sinica
;
(12): 738-741, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-302724
ABSTRACT
<p><b>AIM</b>To evaluate the in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method.</p><p><b>METHODS</b>The characteristics of in vivo release were calculated by deconvolution method using the data of plasma concentration of three kinds of self-designed sustained-release nitrendipine formulations in healthy dogs, in which the in vivo results of nitrendipine solution after oral administrated to dogs were used as weight function. It was the compared with characteristics of in vitro release to assess the in vitro/in vivo correlations.</p><p><b>RESULTS</b>The good correlations of in vitro/in vivo were shown in three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method.</p><p><b>CONCLUSION</b>The deconvolution method exhibited advantage in evaluation of in vitro/in vivo correlation for self-designed sustained-release nitrendipine formulations.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Powders
/
Blood
/
Pharmacokinetics
/
Nitrendipine
/
Administration, Oral
/
Technology, Pharmaceutical
/
Silicone Gels
/
Delayed-Action Preparations
/
Methods
/
Methylcellulose
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article
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