Electrochemical behavior of daunorubicin at Co/GC ion implantation modified electrode and the application of the electrode / 药学学报

ABSTRACT

<p><b>AIM</b>To study the electrochemical behavior of daunorubicin at Co/GC ion implantation modified electrode.</p><p><b>METHODS</b>With Co/GC ion implantation modified electrode as working electrode, daunorubicin was determined by voltammetry in 0.05 mol x L(-1) Na2HPO4-KH2PO4 (pH 6.82) solution.</p><p><b>RESULTS</b>A sensitive reductive peak of daunorubicin was obtained by linear sweep voltammetry. The peak potential was -0.60 V (vs SCE). The peak current was proportional to the concentration of daunorubicin over the range of 2.84 x 10(-8) - 1.42 x 10(-6) mol x L(-1) and 1.42 x 10(-6) - 1.28 x 10(-5) mol x L(-1) with the detection limit of 1.42 x 10(-8) mol x L(-1). The reduction wave was applied to the determination of daunorubicin. The electrochemical behavior and reaction mechanism were studied by linear sweep and cyclic voltammetry.</p><p><b>CONCLUSION</b>The reduction process was quasi-reversible with adsorption characteristics.</p>