Synthesis and anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 518-520, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-302773
ABSTRACT
<p><b>AIM</b>To study the anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives.</p><p><b>METHODS</b>The target compounds were synthesized from p-nitroaniline via three steps and were evaluated for anti-inflammatory activity with the model of xylene-induced ear edema in mice.</p><p><b>RESULTS</b>Eleven compounds were obtained and confirmed by IR, 1HNMR and MS. Some compounds were shown to have significant anti-inflammatory activity.</p><p><b>CONCLUSION</b>N-(4-arylamidophenyl) methanesulfonamide showed appreciable anti-inflammatory activity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Sulfonamides
/
Xylenes
/
Molecular Structure
/
Chemistry
/
Anti-Inflammatory Agents, Non-Steroidal
/
Ear
/
Ear Diseases
/
Edema
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2004
Type:
Article
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