Structural modification and bioactivity of cyclovirobuxine D / 药学学报

ABSTRACT

<p><b>AIM</b>To search for new compounds for the treatment of cardiovascular diseases by structural modification of cyclovirobuxine D.</p><p><b>METHODS</b>According to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.</p><p><b>RESULTS</b>Ten new compounds were syntheized and confirmed by spectra.</p><p><b>CONCLUSION</b>Endurance lacking oxygen activity and antiarrhythmia effects of some analogues of cyclovirobuxine D were tested. Some compounds showed better activity than cyclovirobuxine D.</p>